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구순구개열 환자의 치아 선천결손 유형과 관련 유전자에 관한 고찰
Hypodontia Pattern and Genetic Association in Cleft Lip and Palate Patients

대한구순구개열학회지 2007년 10권 2호 p.81 ~ 88

안효원, 백승학,

소속 상세정보

안효원 ( Ahn Hyo-Won ) - 서울대학교 치의학전문대학원 치과교정학교실
백승학 ( Baek Seung-Hak ) - 서울대학교 치의학전문대학원 교정학교실

KMID : 0952820070100020081

Abstract

Cleft lip and palate (CLP) is one of the most prevalent congenital craniofacial anomalies. It has a significantly greater incidence of dental abnormalities in number, size, shape, and eruption of the teeth. Knout-out mouse model can identify several genes which play an important role in tooth agenesis. Since disruption of these genes has been confirmed to result in tooth agenesis in humans, CLP associated with hypodontia may be the best models for isolated tooth agenesis. According to the studies of dental abnormalities in CLP, the severity of dental defect is known to be influenced by the CLP phenotype. The cumulative data obtained from mouse and human genetic studies indicated that MSX1, PAX9 and AXIN2 are considered as candidate genes in non-syndromic hypodontia, while Shh, Pitx2, Irf6, p63 and EDA pathway genes are involved in syndromic one. We expect that genetic approach of CLP can offer the basis for tooth regeneration and be a new target in hypodontia therapy.